Publications

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Selected Publications

Recent Update: 27th Jan. 2025

2025

• Bray AS, Broberg CA, Hudson AW, Wu W, Nagpal RK, Islam M, Valencia-Bacca JD, Shahid F, Hernandez GE, Nutter NA, Walker KA, Bennett EF, Young TM, Barnes AJ, Ornelles DA, Miller VL, Zafar MA. Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistance. Nat Commun. 2025 Jan 22;16(1):940. doi: 10.1038/s41467-025-56309-8.

• Vo Q, Simon ZD, Park G, Nacionales DC, Gorski C, Barrios EL, Casadesus G, Efron PA, Moldawer LL, Nagpal R, Chakrabarty P, Febo M. Functional connectivity within sensorimotor cortical and striatal regions is regulated by sepsis in a sex-dependent manner. Neuroimage. 2025 Jan;305:120995. doi: 10.1016/j.neuroimage.2024.120995.

2024

• Munley JA, Kelly LS, Park G, Pons EE, Apple CG, Kannan KB, Bible LE, Efron PA, Nagpal R, Mohr AM. Nonselective beta blockade enhances gut microbiome diversity in a rodent model of trauma, hemorrhage, and chronic stress. J Trauma Acute Care Surg. 2024 Nov 13;. doi: 10.1097/TA.0000000000004461.

• Lin J, Yang J, Cui L, Nagpal R, Singh P, Salazar G, Rao Q, Peng Y, Sun Q. Sturgeon-derived peptide LLLE alleviates colitis via regulating gut microbiota and its metabolites. Curr Res Food Sci. 2024;9:100898. doi: 10.1016/j.crfs.2024.100898.

• Nataraj BH, Ranveer SA, K J, Nagpal R, Behare PV. Immune and microbiome modulatory effects of Limosilactobacillus fermentum NCDC 400 in an immunocompromised mouse model. Microb Pathog. 2024 Nov;196:106927. doi: 10.1016/j.micpath.2024.106927.

• Park G, Kadyan S, Hochuli N, Salazar G, Laitano O, Chakrabarty P, Efron P, Zafar MA, Wilber A, Nagpal R. An enteric bacterial infection triggers neuroinflammation and neurobehavioral impairment in 3xTg-AD transgenic mice. The Journal of Infectious Disease. 2024. doi: 10.1093/infdis/jiae165.

• Pal N, Sharma P, Kumawat M, Singh S, Verma V, Tiwari RR, Sarma DK, Nagpal R, Kumar M. Phage therapy: an alternative treatment modality for MDR bacterial infections. Infect Disease. 2024 Jul 17;:1-33. doi: 10.1080/23744235.2024.2379492.

• Singar S, Nagpal R, Arjmandi BH, Akhavan NS. Personalized Nutrition: Tailoring Dietary Recommendations through Genetic Insights. Nutrients. 2024 Aug 13;16(16). doi: 10.3390/nu16162673.

• Khalili L, Park G, Nagpal R, Salazar G. The Role of Akkermansia muciniphila on Improving Gut and Metabolic Health Modulation: A Meta-Analysis of Preclinical Mouse Model Studies . Microorganisms. 2024 Aug 9;12(8):1627. doi: 10.3390/microorganisms12081627

• Munley JA, Kelly LS, Park G, Pons EE, Kannan KB, Bible LE, Efron PA, Nagpal R, Mohr AM. Postinjury Pneumonia Induces a Unique Blood Microbiome Signature. Shock. 2024 Aug 8;. doi: 10.1097/SHK.0000000000002428.

• Singar S, Kadyan S, Patoine C, Park G, Arjmandi B, Nagpal R. The Effects of Almond Consumption on Cardiovascular Health and Gut Microbiome: A Comprehensive Review. Nutrients Open 2024 Jun 20;16(12). doi:10.3390/nu16121964.

• Munley JA, Park G, Kelly LS, Kannan KB, Mankowski RT, Casadesus G, Chakrabarty P, Wallet SM, Maile R, Bible LE, Wang B, Moldawer LL, Mohr AM, Nagpal R, Efron PA. Persistence and Sexual Dimorphism of Gut Dysbiosis and Pathobiome after Sepsis and Trauma. Annals of Surgery 2024 Jun 12. doi: 10.1097/SLA.0000000000006385.

• Singh S, Kriti M, Anamika KS, Sarma DK, Verma V, Nagpal R, Mohania D, Tiwari R, Kumar M. Deciphering the Complex Interplay of Risk Factors in Type 2 Diabetes Mellitus: A comprehensive review. Metabolism Open 2024. doi: 10.1016/j.metop.2024.100287.

• Barnes AJ, Bennett EF, Vezina B, Hudson AW, Hernandez GE, Nutter NA, Bray AS, Nagpal R, Wyres KL, Zafar MA. Ethanolamine metabolism through two genetically distinct loci enables Klebsiella pneumoniae to bypass nutritional competition in the gut. Plos Pathogens 2024. doi: 10.1371/journal.ppat.1012189.

• B Yadav, SS Bhattacharya, L Rosen, R Nagpal, H Yadav, JS Yadav. Oro-Respiratory Dysbiosis and Its Modulatory Effect on Lung Mucosal Toxicity during Exposure or Co-Exposure to Carbon Nanotubes and Cigarette Smoke. Nanomaterials  2024. doi: org/10.3390/nano14030314.

• Munley JA, Kelly LS, Park G, Drury SK, Gillies GS, Coldwell PS, Kannan KB, Bible LE, Efron PA, Nagpal R, Mohr AM. Acute Emergence of the Intestinal Pathobiome after Postinjury Pneumonia. Journal of Trauma Acute Care Surgery 2024 Mar 14. doi: 10.1097/TA.0000000000004300. PMID: 38480488.

• Park G, Kadyan S, Hochuli N, Pollak J, Wang B, Salazar G, Chakrabarty P, Efron P, Sheffler J, Nagpal R. A modified Mediterranean-style diet enhances brain function via specific gut-microbiome-brain mechanisms. Gut Microbes 2024. doi: 10.1080/19490976.2024.2323752.

• Nataraj BH, Jeevan K, Dang AK, Nagpal R, Ali SA, Behare PV. Pre-clinical safety and toxicity assessment of Limosilactobacillus fermentum NCDC 400 in murine model. Microbial Pathogenesis 2024; 189:106589. doi: 10.1016/j.micpath.2024.106589. PMID: 38382627.

• Yadav B, Bhattacharya SS, Rosen L, Nagpal R, Yadav H, Yadav JS. Oro-Respiratory Dysbiosis and Its Modulatory Effect on Lung Mucosal Toxicity during Exposure or Co-Exposure to Carbon Nanotubes and Cigarette Smoke. Nanomaterials. 2024; 14(3):314. doi: doi.org/10.3390/nano14030314.
• Kadyan S, Park G, Hochuli N, Miller K, Wang B, Nagpal R. Resistant starches from dietary pulses improve neurocognitive health via gut-microbiomebrain axis in aged mice. Frontiers in Nutrition. 2024 Jan 24;11:1322201. doi: doi.org/10.3389/fnut.2024.1322201.
• Dawson MA, Cheung SN, La Frano MR, Nagpal R, Berryman CE. Early time-restricted eating improves markers of cardiometabolic health but has no impacton intestinal nutrient absorption in healthy adults. Cell Rep Med. 2024 Jan 16;5(1):101363. doi: 10.1016/j.xcrm.2023.101363. PMID: 38232698.
• Park G, Munley JA, Kelly LS, Kannan KB, Mankowski RT, Sharma A, Upchurch G,Casadesus G, Chakrabarty P, Wallet SM, Maile R, Bible LE, Wang B, Moldawer LL, Mohr AM, Efron PA, Nagpal R. Gut mycobiome dysbiosis after sepsis and trauma. Crit Care. 2024 Jan 11;28(1):18. doi: 10.1186/s13054-023-04780-4. PMID:38212826; PMCID: PMC10785534.
• Hochuli N, Kadyan S, Park G, Patoine C, Nagpal R. Pathways linking microbiota-gut-brain axis with neuroinflammatory mechanisms in Alzheimer’s pathophysiology. Microbiome Research Reports. 2023 Dec 6. www.oaepublish.com/articles/mrr.2023.39.

2023

• Munley JA, Kelly LS, Park G, Gillies GS, Pons EE, Kannan KB, Bible LE, Efron PA, Nagpal R, Mohr AM. Sex-specific intestinal dysbiosis persists after multicompartmental injury. Surgery. 2023 Oct 11:S0039-6060(23)00524-X. doi:10.1016/j.surg.2023.08.023. Epub ahead of print. PMID: 37833155.
• Singh S, Sarma DK, Verma V, Nagpal R, Kumar M. Unveiling the future of metabolic medicine: omics technologies driving personalized solutions for precision treatment of metabolic disorders. Biochem Biophys Res Commun. 2023 Nov 19;682:1-20. doi: 10.1016/j.bbrc.2023.09.064. Epub 2023 Sep 29. PMID: 37788525.
• Singh S, Sarma DK, Verma V, Nagpal R, Kumar M. From Cells to Environment: Exploring the Interplay between Factors Shaping Bone Health and Disease. Medicina (Kaunas). 2023 Aug 25;59(9):1546. doi: 10.3390/medicina59091546. PMID: 37763665; PMCID: PMC10532995.
• Munley JA, Kirkpatrick SL, Gillies GS, Bible LE, Efron PA, Nagpal R, Mohr AM. The Intestinal Microbiome after Traumatic Injury. Microorganisms. 2023 Aug 2;11(8):1990. doi: 10.3390/microorganisms11081990. PMID: 37630549; PMCID: PMC10459834.
• Ellouze I, Sheffler J, Nagpal R, Arjmandi B. Dietary Patterns and Alzheimer's Disease: An Updated Review Linking Nutrition to Neuroscience. Nutrients. 2023 Jul 19;15(14):3204. doi: 10.3390/nu15143204. PMID: 37513622; PMCID: PMC10384681.
• Kadyan S, Park G, Wang B, Nagpal R. Dietary fiber modulates gut microbiome and metabolome in a host sex-specific manner in a murine model of aging. Front Mol Biosci. 2023 Jun 15;10:1182643. doi: 10.3389/fmolb.2023.1182643. PMID:37457834; PMCID: PMC10345844.
• Kadyan S, Park G, Wang B, Singh P, Arjmandi B, Nagpal R. Resistant starches from dietary pulses modulate the gut metabolome in association with microbiome in a humanized murine model of ageing. Sci Rep. 2023 Jun 29;13(1):10566. doi: 10.1038/s41598-023-37036-w. PMID: 37386089; PMCID: PMC10310774.
• Bouch RJ, Zhang J, Miller BC, Robbins CJ, Mosher TH, Li W, Krupenko SA, Nagpal R, Zhao J, Bloomfeld RS, Lu Y, Nikiforov MA, Song Q, He Z. Distinct inflammatory Th17 subsets emerge in autoimmunity and infection. J Exp Med. 2023 Oct 2;220(10):e20221911. doi: 10.1084/jem.20221911. Epub 2023 Jun 27. PMID: 37367944; PMCID: PMC10300431.
• Polcz VE, Barrios EL, Chapin B, Price CC, Nagpal R, Chakrabarty P, Casadesus G, Foster T, Moldawer LL, Efron PA. Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection. Clin Sci (Lond). 2023 Jun 28;137(12):963-978. doi: 10.1042/CS20220555. PMID: 37337946; PMCID: PMC10285043.
• Nataraj BH, Shashank Gowda BG, Kapila S, Arora S, Puniya AK, Nagpal R, Behare PV. Influence of exopolysaccharide EPSKar1-iron complexation on iron bioavailability and alleviating iron deficiency anaemia in Wistar rats. Food Funct. 2023 May 22;14(10):4931-4947. doi: 10.1039/d2fo03352f. PMID: 37158475.
• Singh TP, Kadyan S, Devi H, Park G, Nagpal R. Gut microbiome as a therapeutic target for liver diseases. Life Sci. 2023 Jun 1;322:121685. doi: 10.1016/j.lfs.2023.121685. Epub 2023 Apr 10. PMID: 37044173.
• Singh S, Sharma P, Sarma DK, Kumawat M, Tiwari R, Verma V, Nagpal R, Kumar M. Implication of Obesity and Gut Microbiome Dysbiosis in the Etiology of Colorectal Cancer. Cancers (Basel). 2023 Mar 22;15(6):1913. doi: 10.3390/cancers15061913. PMID: 36980799; PMCID: PMC10047102.
• Kumari M, Kumari R, Nataraj BH, Shelke PA, Ali SA, Nagpal R, Behare PV. Physicochemical and rheological characterizations of a novel exopolysaccharide EPSKar1 and its iron complex EPSKar1-Fe: Towards potential iron-fortification applications. Curr Res Food Sci. 2023 Mar 6;6:100478. doi: 10.1016/j.crfs.2023.100478. PMID: 36935848; PMCID: PMC10017363.
• Centner AM, Khalili L, Ukhanov V, Kadyan S, Nagpal R, Salazar G. The Role of Phytochemicals and Gut Microbiome in Atherosclerosis in Preclinical Mouse Models. Nutrients. 2023 Feb 28;15(5):1212. doi: 10.3390/nu15051212. PMID: 36904211; PMCID: PMC10005405.
• Munley JA, Kelly LS, Park G, Gillies GS, Pons EE, Kannan KB, Whitley EM, Bible LE, Efron PA, Nagpal R, Mohr AM. Multicompartmental traumatic injury induces sex-specific alterations in the gut microbiome. J Trauma Acute Care Surg. 2023 Jul 1;95(1):30-38. doi: 10.1097/TA.0000000000003939. Epub 2023 Mar 6. PMID: 36872509; PMCID: PMC10293079.
• Kadyan S, Park G, Singh P, Arjmandi B, Nagpal R. Prebiotic mechanisms of resistant starches from dietary beans and pulses on gut microbiome and metabolic health in a humanized murine model of aging. Front Nutr. 2023 Feb 7;10:1106463. doi: 10.3389/fnut.2023.1106463. PMID: 36824174; PMCID: PMC9941547.
• Munley JA, Kelly LS, Pons EE, Kannan KB, Coldwell PS, Whitley EM, Gillies GS, Efron PA, Nagpal R, Mohr AM. Multicompartmental traumatic injury and the microbiome: Shift to a pathobiome. J Trauma Acute Care Surg. 2023 Jan 1;94(1):15-22. doi: 10.1097/TA.0000000000003803. Epub 2022 Oct 7. PMID: 36203239; PMCID: PMC9805505.

2022

• Munley JA, Nagpal R, Hanson NC, Mirzaie A, Laquian L, Mohr AM, Efron PA, Arnaoutakis DJ, Cooper MA. Chronic mesenteric ischemia-induced intestinal dysbiosis resolved after revascularization. J Vasc Surg Cases Innov Tech. 2022 Dec 23;9(2):101084. doi: 10.1016/j.jvscit.2022.101084. PMID: 36970136; PMCID: PMC10033993.
• James MM, Pal N, Sharma P, Kumawat M, Shubham S, Verma V, Tiwari RR, Singh B, Nagpal R, Sarma DK, Kumar M. Role of butyrogenic Firmicutes in type-2 diabetes. J Diabetes Metab Disord. 2022 Jul 14;21(2):1873-1882. doi: 10.1007/s40200-022-01081-5. PMID: 36404833; PMCID: PMC9672246.
• Kumari M, Dasriya VL, Nataraj BH, Nagpal R, Behare PV. Lacticaseibacillus rhamnosus-Derived Exopolysaccharide Attenuates D-Galactose-Induced Oxidative Stress and Inflammatory Brain Injury and Modulates Gut Microbiota in a Mouse Model. Microorganisms. 2022 Oct 17;10(10):2046. doi: 10.3390/microorganisms10102046. PMID: 36296322; PMCID: PMC9611687.
• Clark M, Centner AM, Ukhanov V, Nagpal R, Salazar G. Gallic acid ameliorates atherosclerosis and vascular senescence and remodels the microbiome in a sex- dependent manner in ApoE-/- mice. J Nutr Biochem. 2022 Dec;110:109132. doi: 10.1016/j.jnutbio.2022.109132. Epub 2022 Aug 24. PMID: 36028099.
• Singh S, Sharma P, Pal N, Kumawat M, Shubham S, Sarma DK, Tiwari RR, Kumar M, Nagpal R. Impact of Environmental Pollutants on Gut Microbiome and Mental Health via the Gut-Brain Axis. Microorganisms. 2022 Jul 19;10(7):1457. doi: 10.3390/microorganisms10071457. PMID: 35889175; PMCID: PMC9317668.
• Kumar M, James MM, Kumawat M, Nabi B, Sharma P, Pal N, Shubham S, Tiwari RR, Sarma DK, Nagpal R. Aging and Microbiome in the Modulation of Vaccine Efficacy. Biomedicines. 2022 Jun 29;10(7):1545. doi: 10.3390/biomedicines10071545. PMID: 35884849; PMCID: PMC9313064.
• Srivastava U, Nataraj BH, Kumari M, Kadyan S, Puniya AK, Behare PV, Nagpal R. Antioxidant and immunomodulatory potency of Lacticaseibacillus rhamnosus NCDC24 fermented milk-derived peptides: A computationally guided in-vitro and ex-vivo investigation. Peptides. 2022 Sep;155:170843. doi:10.1016/j.peptides.2022.170843. Epub 2022 Jul 22. PMID: 35878657.
• Bhattacharya SS, Yadav B, Rosen L, Nagpal R, Yadav H, Yadav JS. Crosstalk between gut microbiota and lung inflammation in murine toxicity models of respiratory exposure or co-exposure to carbon nanotube particles and cigarette smoke extract. Toxicol Appl Pharmacol. 2022 Jul 15;447:116066. doi: 10.1016/j.taap.2022.116066. Epub 2022 May 18. PMID: 35595072.
• Kadyan S, Sharma A, Arjmandi BH, Singh P, Nagpal R. Prebiotic Potential of Dietary Beans and Pulses and Their Resistant Starch for Aging-Associated Gut and Metabolic Health. Nutrients. 2022 Apr 21;14(9):1726. doi: 10.3390/nu14091726. PMID: 35565693; PMCID: PMC9100130.
• Kumar M, Pal N, Sharma P, Kumawat M, Sarma DK, Nabi B, Verma V, Tiwari RR, Shubham S, Arjmandi B, Nagpal R. Omega-3 Fatty Acids and Their Interaction with the Gut Microbiome in the Prevention and Amelioration of Type-2 Diabetes. Nutrients. 2022 Apr 21;14(9):1723. doi: 10.3390/nu14091723. PMID: 35565691; PMCID: PMC9104474.
• Kumar M, Nagpal R, Kumar R, Hemalatha R, Verma V, Kumar A, Chakraborty C, Singh B, Marotta F, Jain S, Yadav H. Corrigendum to "Cholesterol-Lowering Probiotics as Potential Biotherapeutics for Metabolic Diseases". J Diabetes Res. 2022 Apr 1;2022:3952529. doi: 10.1155/2022/3952529. Erratum for: Exp Diabetes Res. 2012;2012:902917. PMID: 35399706; PMCID: PMC8993570.
• Sarma DK, Kumar M, Dhurve J, Pal N, Sharma P, James MM, Das D, Mishra S, Shubham S, Kumawat M, Verma V, Tiwari RR, Nagpal R, Marotta F. Influence of Host Blood Meal Source on Gut Microbiota of Wild Caught Aedes aegypti, a Dominant Arboviral Disease Vector. Microorganisms. 2022 Feb 1;10(2):332. doi: 10.3390/microorganisms10020332. PMID: 35208787; PMCID: PMC8880539.

2021

• Kumari M, Singh P, Nataraj BH, Kokkiligadda A, Naithani H, Azmal Ali S, Behare PV, Nagpal R. Fostering next-generation probiotics in human gut by targeted dietary modulation: An emerging perspective. Food Res Int. 2021 Dec;150(Pt A):110716. doi: 10.1016/j.foodres.2021.110716. Epub 2021 Sep 30. PMID: 34865747.
• Nagpal R, Indugu N, Singh P. Distinct Gut Microbiota Signatures in Mice Treated with Commonly Used Food Preservatives. Microorganisms. 2021 Nov 7;9(11):2311. doi: 10.3390/microorganisms9112311. PMID: 34835437; PMCID: PMC8617889.
• Rejeski JJ, Wilson FM, Nagpal R, Yadav H, Weinberg RB. The Impact of a Mediterranean Diet on the Gut Microbiome in Healthy Human Subjects: A Pilot Study. Digestion. 2022;103(2):133-140. doi: 10.1159/000519445. Epub 2021 Nov 8. PMID: 34749376; PMCID: PMC8916822.
• Kumar M, Sarma DK, Shubham S, Kumawat M, Verma V, Singh B, Nagpal R, Tiwari RR. Mucormycosis in COVID-19 pandemic: Risk factors and linkages. Curr Res Microb Sci. 2021 Dec;2:100057. doi: 10.1016/j.crmicr.2021.100057. Epub 2021 Aug 8. PMID: 34396355; PMCID: PMC8349419.
• Vasundhara D, Raju VN, Hemalatha R, Nagpal R, Kumar M. Vaginal & gut microbiota diversity in pregnant women with bacterial vaginosis & effect of oral probiotics: An exploratory study. Indian J Med Res. 2021 Apr;153(4):492-502. doi: 10.4103/ijmr.IJMR_350_19. PMID: 34380796; PMCID: PMC8354056.
• Kumar S, Nagpal R, Kumar A, Ashraf MU, Bae YS. Immunotherapeutic Potential of m6A-Modifiers and MicroRNAs in Controlling Acute Myeloid Leukaemia. Biomedicines. 2021 Jun 18;9(6):690. doi: 10.3390/biomedicines9060690. PMID: 34207299; PMCID: PMC8234128.
• Nataraj BH, Shivanna SK, Rao P, Nagpal R, Behare PV. Evolutionary concepts in the functional biotics arena: a mini-review. Food Sci Biotechnol. 2020 Sep 16;30(4):487-496. doi: 10.1007/s10068-020-00818-3. PMID: 33936839; PMCID: PMC8050181.
• Kincaid HJ, Nagpal R, Yadav H. Diet-Microbiota-Brain Axis in Alzheimer's Disease. Ann Nutr Metab. 2021;77 Suppl 2(Suppl 2):21-27. doi: 10.1159/000515700. Epub 2021 Apr 27. PMID: 33906194; PMCID: PMC10202336.
• Miller B, Mainali R, Nagpal R, Yadav H. A Newly Developed Synbiotic Yogurt Prevents Diabetes by Improving the Microbiome-Intestine-Pancreas Axis. Int J Mol Sci. 2021 Feb 6;22(4):1647. doi: 10.3390/ijms22041647. PMID: 33562070; PMCID: PMC7915949.
• Sharma L, Nagpal R, Jackson CR, Patel D, Singh P. Antibiotic-resistant bacteria and gut microbiome communities associated with wild-caught shrimp from the United States versus imported farm-raised retail shrimp. Sci Rep. 2021 Feb 8;11(1):3356. doi: 10.1038/s41598-021-82823-y. PMID: 33558614; PMCID: PMC7870836.
• Saccon TD, Nagpal R, Yadav H, Cavalcante MB, Nunes ADC, Schneider A, Gesing A, Hughes B, Yousefzadeh M, Tchkonia T, Kirkland JL, Niedernhofer LJ, Robbins PD, Masternak MM. Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice. J Gerontol A Biol Sci Med Sci. 2021 Oct 13;76(11):1895-1905. doi: 10.1093/gerona/glab002. PMID: 33406219; PMCID: PMC851407